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1. (WO2017180913) TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS
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Pub. No.: WO/2017/180913 International Application No.: PCT/US2017/027488
Publication Date: 19.10.2017 International Filing Date: 13.04.2017
IPC:
C07K 16/24 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/32 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
YANG, Zhi-Yong [US/US]; US (US)
SANOFI [FR/FR]; 54, Rue la Boetie 75008 Paris, FR
Inventors:
YANG, Zhi-Yong; US
NABEL, Gary, J.; US
WU, Lan; US
SEUNG, Edward; US
WEI, Ronnie; US
BENINGA, Jochen; DE
RAO, Ercole; DE
LEUSCHNER, Wulf Dirk; DE
BEIL, Christian; DE
LANGE, Christian; DE
CORVEY, Carsten; DE
Agent:
JONES, Kevin; US
BANKO, Max; US
AIKEN, Charity; US
JONES, Kevin; US
ARJOMAND, Mehran; US
Priority Data:
62/322,03613.04.2016US
62/331,19103.05.2016US
62/412,18724.10.2016US
EP17305298.617.03.2017EP
Title (EN) TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS
(FR) PROTÉINES DE LIAISON TRISPÉCIFIQUES ET/OU TRIVALENTES
Abstract:
(EN) The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
(FR) L'invention concerne des compositions comprenant des protéines de liaison trispecifiques et/ou trivalentes comprenant quatre chaînes polypeptidiques qui forment trois sites de liaison à l'antigène qui se lient spécifiquement à une ou plusieurs protéines cibles, une première paire de polypeptides qui forme la protéine de liaison possédant des domaines variables doubles ayant une orientation croisée et une seconde paire de polypeptides qui forme la protéine de liaison possédant un domaine variable unique. L'invention concerne également des procédés de production de protéines de liaison trispécifiques et/ou trivalentes et des utilisations de telles protéines de liaison.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)