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|1. (WO2017180616) DNA CONSTRUCTS FOR MANUFACTURING BIO-THERAPEUTIC POLYPEPTIDES FOR USE IN ANIMAL VACCINES AND THERAPEUTICS|
|Inventors:||MACKENZIE-LAMB, Viktor Antonio
JEGATHESE, Simon Porphy
|Title:||DNA CONSTRUCTS FOR MANUFACTURING BIO-THERAPEUTIC POLYPEPTIDES FOR USE IN ANIMAL VACCINES AND THERAPEUTICS|
A nucleic acid constructs including a heterologous nucleotide sequence operably linked to a constitutively active promoter; a 5' recombination sequence at a 5' end of the construct and a 3' recombination sequence at a 3' end of the construct, wherein the recombination sequences are configured for homologous recombination into a genome of a microalgal host cell; and optionally a bacterial 5' untranslated region (5'UTR) between the 5' recombination sequence and the promoter, and a bacterial 3' untranslated region (3'UTR) between the 3' recombination sequence and the heterologous nucleotide sequence.