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1. (WO2017180616) DNA CONSTRUCTS FOR MANUFACTURING BIO-THERAPEUTIC POLYPEPTIDES FOR USE IN ANIMAL VACCINES AND THERAPEUTICS

Pub. No.:    WO/2017/180616    International Application No.:    PCT/US2017/026995
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Wed Apr 12 01:59:59 CEST 2017
IPC: C12N 15/79
C12N 15/67
C12N 15/64
C12N 15/113
C07K 14/405
C07K 14/005
A61K 39/12
A23K 50/80
A23K 10/18
A23K 20/147
A61K 39/05
C07K 14/195
C07K 16/12
Applicants: MICROSYNBIOTIX, LTD.
Inventors: MACKENZIE-LAMB, Viktor Antonio
JEGATHESE, Simon Porphy
KWON, Kwang-Chul
Title: DNA CONSTRUCTS FOR MANUFACTURING BIO-THERAPEUTIC POLYPEPTIDES FOR USE IN ANIMAL VACCINES AND THERAPEUTICS
Abstract:
A nucleic acid constructs including a heterologous nucleotide sequence operably linked to a constitutively active promoter; a 5' recombination sequence at a 5' end of the construct and a 3' recombination sequence at a 3' end of the construct, wherein the recombination sequences are configured for homologous recombination into a genome of a microalgal host cell; and optionally a bacterial 5' untranslated region (5'UTR) between the 5' recombination sequence and the promoter, and a bacterial 3' untranslated region (3'UTR) between the 3' recombination sequence and the heterologous nucleotide sequence.