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1. (WO2017180389) COMBINATION THERAPY WITH NOTCH AND CDK4/6 INHIBITORS FOR THE TREATMENT OF CANCER

Pub. No.:    WO/2017/180389    International Application No.:    PCT/US2017/026134
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Thu Apr 06 01:59:59 CEST 2017
IPC: A61K 31/444
A61K 31/506
A61K 31/55
A61P 35/00
A61P 35/02
Applicants: ELI LILLY AND COMPANY
Inventors: BECKMANN, Richard Paul
PATEL, Bharvin Kumar
Title: COMBINATION THERAPY WITH NOTCH AND CDK4/6 INHIBITORS FOR THE TREATMENT OF CANCER
Abstract:
Medicaments for use in treating acute myelogenous leukemia, chronic myelogenous leukemia, breast cancer, ovarian cancer, malignant melanoma, lung cancer, pancreatic cancer, glioblastoma, sarcoma, desmoid tumors, adenoid cystic carcinoma (ACC), colorectal cancer, prostate cancer, or medulloblastoma in a patient by administering simultaneously, separately, or sequentialy, 4,4,4-trifluoro-N-[(IS)-2-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo-ethyl]butanamide, or a pharmaceutically acceptable salt or hydrate thereof, and N-[5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine, or a pharmaceutically acceptable salt thereof.