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1. WO2017179976 - MEANS AND METHODS FOR THE N-DEALKYLATION OF AMINES

Publication Number WO/2017/179976
Publication Date 19.10.2017
International Application No. PCT/NL2017/050226
International Filing Date 13.04.2017
IPC
C07C 213/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07D 451/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo octane or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane; Cyclic acetals thereof
04with hetero atoms directly attached in position 3 of the 8-azabicyclo octane or in position 7 of the 3-oxa-9-azatricyclo nonane ring system
06Oxygen atoms
12acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
C07C 231/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
B01J 23/52 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
23Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/113
38of noble metals
48Silver or gold
52Gold
CPC
B01J 23/52
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
23Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
38of noble metals
48Silver or gold
52Gold
B01J 25/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
25Catalysts of the Raney type
B01J 35/0033
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
35Catalysts, in general, characterised by their form or physical properties
002Catalysts characterised by their physical properties
0033Electric or magnetic properties
B01J 35/1061
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
35Catalysts, in general, characterised by their form or physical properties
02Solids
10characterised by their surface properties or porosity
1052Pore diameter
10612-50 nm
B01J 37/06
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
37Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
06Washing
C07C 213/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
Applicants
  • RIJKSUNIVERSITEIT GRONINGEN [NL]/[NL]
  • STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN [NL]/[NL]
Inventors
  • YUAN, Tao
  • BISCHOFF, Rainer Paul Hermann
  • PERMENTIER, Hjalmar Petrus
Agents
  • JANSEN, C.M.
Priority Data
16165298.714.04.2016EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEANS AND METHODS FOR THE N-DEALKYLATION OF AMINES
(FR) MOYENS ET PROCÉDÉS DE N-DÉSALKYLATION D’AMINES
Abstract
(EN)
The invention relates to improved means and methods for N- dealkylation of alkylated amines. Provided is a method for the catalytic N- dealkylation of an N-alkylated amine substrate, comprising incubating said amine substrate in a suitable solvent in the presence of a nanoporous gold (NPG) surface and allowing for the formation of an N-dealkylation product. Also provided is a reaction mixture comprising an N-alkylated amine substrate in a suitable solvent and a NPG surface.
(FR)
L'invention concerne des moyens et des procédés améliorés de N-désalkylation d'amines alkylées. L'invention concerne un procédé de N-désalkylation catalytique d'un substrat amine N-alkylé, consistant à incuber ledit substrat amine dans un solvant approprié en présence d'une surface d’or nanoporeux (NPG) et à permettre la formation d'un produit de N-désalkylation. L'invention concerne également un mélange réactionnel comprenant un substrat amine N-alkylé dans un solvant approprié et une surface de NPG.
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