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1. (WO2017179840) COMPOSITION FOR TREATING CHRONIC PULMONARY DISEASE, COMPRISING EXOSOME DERIVED FROM THROMBIN-TREATED STEM CELL
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Pub. No.: WO/2017/179840 International Application No.: PCT/KR2017/003471
Publication Date: 19.10.2017 International Filing Date: 30.03.2017
IPC:
A61K 35/28 (2015.01) ,A61K 35/30 (2015.01) ,A61K 35/34 (2015.01) ,A61K 35/35 (2015.01) ,A61K 35/50 (2015.01) ,A61K 35/51 (2015.01) ,A61K 38/48 (2006.01) ,A61K 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
30
Nerves; Brain
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
34
Muscles; Heart
[IPC code unknown for A61K 35/35]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
48
Reproductive organs; Embryos
50
Placenta; Amniotic fluid
[IPC code unknown for A61K 35/51]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
Applicants:
사회복지법인 삼성생명공익재단 SAMSUNG LIFE PUBLIC WELFARE FOUNDATION [KR/KR]; 서울시 용산구 이태원로55길 48 48, Itaewon-ro 55-gil Yongsan-gu Seoul 04348, KR
Inventors:
장윤실 CHANG, Yun Sil; KR
박원순 PARK, Won Soon; KR
성동경 SUNG, Dong Kyung; KR
안소윤 AHN, So Yoon; KR
Agent:
특허법인 아이시스 ISIS IP LAW LLC; 서울시 강남구 테헤란로63길 14, 8층 8F., 14, Teheran-ro 63-gil Gangnam-gu Seoul 06160, KR
Priority Data:
10-2016-004619715.04.2016KR
Title (EN) COMPOSITION FOR TREATING CHRONIC PULMONARY DISEASE, COMPRISING EXOSOME DERIVED FROM THROMBIN-TREATED STEM CELL
(FR) COMPOSITION POUR LE TRAITEMENT D'UNE MALADIE PULMONAIRE CHRONIQUE, COMPRENANT UN EXOSOME DÉRIVÉ DE CELLULES SOUCHES TRAITÉES PAR LA THROMBINE
(KO) 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물
Abstract:
(EN) The present invention relates to a pharmaceutical composition for preventing or treating chronic pulmonary disease, a pharmaceutical formulation containing the same, and a method for preparing the same, the composition comprising as an active ingredient an exosome derived from thrombin-treated stem cells. According to an exosome-based therapeutic agent of the present invention, the therapeutic agent is advantageous in that since the therapeutic agent is a cell-free preparation, the risk of carcinogenesis is low and there is no problem of transplant rejection reaction, and furthermore, there is no possibility of causing the occlusion of the microvascular system upon systemic administration, and since the therapeutic agent is a non-cell separating material, it is possible to develop a pharmaceutical agent as an off-the-shelf product, thereby reducing the manufacturing cost, and the therapeutic agent has an excellent therapeutic effect for chronic pulmonary disease with a low concentration of exosome by virtue of the thrombin treatment effect.
(FR) La présente invention concerne une composition pharmaceutique pour prévenir ou traiter une maladie pulmonaire chronique, une formulation pharmaceutique contenant celle-ci, et un procédé de préparation de celle-ci, la composition comprenant, en tant que substance active, un exosome dérivé de cellules souches traitées par la thrombine. Selon un agent thérapeutique à base d'exosome de la présente invention, l'agent thérapeutique est avantageux en ce que, étant donné que l'agent thérapeutique est une préparation sans cellules, le risque de carcinogenèse est faible et il n'y a pas de problème de réaction de rejet de greffe, et en outre, il n'y a pas de possibilité de causer l'occlusion du système microvasculaire lors d’une administration systémique et, étant donné que l'agent thérapeutique est un matériau de séparation non cellulaire, il est possible de développer un agent pharmaceutique sous la forme d'un produit prêt à l’usage, de façon à réduire le coût de fabrication, et l'agent thérapeutique a un excellent effet thérapeutique pour une maladie pulmonaire chronique avec une faible concentration d'exosome grâce à l'effet du traitement par la thrombine.
(KO) 본 발명은, 트롬빈 처리된 줄기세포에서 유래된 엑소좀(exosome)을 유효성분으로 포함하는, 만성 폐질환(Chronic Pulmonary Disease)의 예방 또는 치료용 약학적 조성물, 이를 함유하는 약학 제제, 및 이의 제조방법에 관한 것이다. 본 발명의 엑소좀 기반 치료제에 의하면, cell-free 제제이기 때문에 발암의 위험성이 적고 이식거부 반응의 문제가 없을 뿐만 아니라, 전신 투여시 미세혈관에 폐색을 일으킬 우려가 없으며, 세포가 아닌 분리물질로써 off the shelf 제품으로의 약제 개발이 가능하므로 제조단가를 줄일 수 있고, 트롬빈 처리 효과에 의해 낮은 농도의 엑소좀으로도 만성 폐질환 치료 효과가 우수하다는 장점이 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)