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1. (WO2017179766) METHOD FOR PREPARING GRAM-POSITIVE BACTERIAL GHOSTS BY HYDROCHLORIC ACID TREATMENT
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Pub. No.: WO/2017/179766 International Application No.: PCT/KR2016/007591
Publication Date: 19.10.2017 International Filing Date: 13.07.2016
IPC:
C12N 1/20 (2006.01) ,C12N 1/06 (2006.01) ,A61K 39/02 (2006.01) ,A61K 39/07 (2006.01) ,A61K 39/085 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
06
Lysis of micro-organisms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
07
Bacillus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
085
Staphylococcus
Applicants: PAICHAI UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION[KR/KR]; (Doma-dong) 155-40, Baejae-ro, Seo-gu, Daejeon 35345, KR
Inventors: CHOI, Chang Won; KR
JI, Seong Mi; KR
PARK, Hyun Jung; KR
OH, Sung; KR
VINOD, Nagarajan; KR
NO, Han Byul; KR
Agent: ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM; (Banpo-dong) 3rd floor, 108, Sapyeong-daero, Seocho-gu, Seoul 06575, KR
Priority Data:
10-2016-004646615.04.2016KR
Title (EN) METHOD FOR PREPARING GRAM-POSITIVE BACTERIAL GHOSTS BY HYDROCHLORIC ACID TREATMENT
(FR) MÉTHODE DE PRÉPARATION DE FANTÔMES DE BACTÉRIES GRAM POSITIF PAR TRAITEMENT À L'ACIDE CHLORHYDRIQUE
(KO) 염산 처리에 의한 그람양성 박테리아 고스트의 제조 방법
Abstract:
(EN) The present invention relates to gram-positive bacterial ghosts prepared by hydrochloric acid treatment and a method for preparing the same. More particularly, the gram-positive bacillus bacterial ghosts prepared according to the method of the present invention can be effectively formed as bacterial ghosts when treated and cultured with a minimal inhibitory concentration (MIC) of hydrochloric acid capable of inhibiting the production of live bacteria colonies of gram-positive bacillus. Also, since the formed bacterial ghosts are configured such that the shape of the envelope of a cell is intactly preserved and proteins or DNAs in the cytoplasm do not remain, there is little risk of side effects such as secondary infections due to proliferation, when administered into the body. Accordingly, the bacterial ghosts of gram-positive bacillus prepared according to the method of the present invention can be effectively used as a vaccine or a foreign antigen carrier for the prevention or treatment of gram-positive bacillus infectious diseases.
(FR) La présente invention concerne des fantômes de bactéries gram positif préparés par traitement à l'acide chlorhydrique et une méthode de préparation de ces derniers. Plus particulièrement, les fantômes bactériens de bacilles gram positif préparés selon la méthode de la présente invention peuvent être efficacement formés en tant que fantômes bactériens lorsque les bacilles gram positif sont traités et cultivés avec une concentration minimale inhibitrice (CMI) d'acide chlorhydrique capable d'inhiber la production de colonies bactériennes vivantes de bacilles gram positif. En outre, étant donné que les fantômes bactériens formés sont configurés de telle sorte que la forme de l'enveloppe des cellules est préservée intacte et que les protéines ou l'ADN du cytoplasme ne sont pas conservés, il n'y a que peu de risques d'effets indésirables tels que des infections secondaires dues à une prolifération, lorsque ces derniers sont administrés à l'organisme. En conséquence, les fantômes bactériens de bacilles gram positif préparés selon la méthode de la présente invention peuvent être efficacement utilisés en tant que vaccin ou en tant que support d'un antigène du non-soi pour la prévention ou le traitement de maladies infectieuses provoquées par des bacilles gram positif.
(KO) 본 발명은 염산 처리에 의해 제조된 그람양성 박테리아 고스트 및 이의 제조 방법에 관한 것으로, 구체적으로 본 발명의 방법에 따라 제조된 그람양성균 박테리아 고스트는 그람양성균의 생균 콜로니 생성을 억제할 수 있는 염산의 최소 억제 농도(MIC)을 처리하여 배양하였을 때, 효과적으로 박테리아 고스트로 형성될 수 있으며, 상기 형성된 박테리아 고스트는 세포의 외막 형태를 온전히 보존하면서 세포질 내 단백질 또는 DNA가 잔존하지 않은 형태이기 때문에, 체내에 투여되었을 때 증식에 의한 2차 감염증 등의 부작용에 대한 위험이 적으므로, 본 발명의 방법에 따라 제조된 그람양성균의 박테리아 고스트는 그람양성균 감염증의 예방 또는 치료용 백신 또는 외래 항원 운반체로서 효과적으로 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)