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1. (WO2017179015) COMPOSITIONS FOR THE TREATMENT OF CANCER

Pub. No.:    WO/2017/179015    International Application No.:    PCT/IB2017/052156
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Fri Apr 14 01:59:59 CEST 2017
IPC: C07K 14/725
A61K 39/00
C07K 14/445
C08B 37/00
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Inventors: ALONSO-FERRERO, Maria
BRITTEN, Cedrik M.
SLAOUI, Moncef Mohammed
SOUTHGATE, Thomas
Title: COMPOSITIONS FOR THE TREATMENT OF CANCER
Abstract:
The present invention provides chimeric antigen receptors (CARs) comprising: a target binding domain capable of selectively binding placenta-like chondroitin sulfate A (pl-CSA); a spacer region; a transmembrane domain; and at least one costimulatory domain. In one embodiment, methods of treating cancer in a human are provided comprising administering the immunomodulatory cell of the present invention said human. In one embodiment, the methods further comprising expanding a population of said engineered immunomodulatory cell ex vivo prior to administering to said human are provided.