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1. (WO2017178915) NON-UNIFORMLY STIFF POLYMERIC SCAFFOLDS AND METHODS FOR PRODUCING THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/178915 International Application No.: PCT/IB2017/051796
Publication Date: 19.10.2017 International Filing Date: 29.03.2017
IPC:
A61L 27/24 (2006.01) ,A61L 27/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
24
Collagen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
52
Hydrogels or hydrocolloids
Applicants: NEUTROMEDICS AG[CH/CH]; Alte Steinhauserstrasse 19 6330 Cham, CH
Inventors: FREY, Peter; CH
HUBBELL, Jeffrey A.; US
LARSSON, Hans M.; CH
VARDAR, Elif; CH
BALET, Eva-Maria; CH
VYTHILINGAM, Ganesh; CH
PINNAGODA, Kalitha; CH
Agent: ROLAND, André; CH
Priority Data:
PCT/IB2016/05209613.04.2016IB
Title (EN) NON-UNIFORMLY STIFF POLYMERIC SCAFFOLDS AND METHODS FOR PRODUCING THEREOF
(FR) ÉCHAFAUDAGES POLYMÈRES NON UNIFORMÉMENT RIGIDES ET PROCÉDÉS DE FABRICATION ASSOCIÉS
Abstract:
(EN) The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.
(FR) L'invention concerne des procédés de production d'un échafaudage polymère destiné à être utilisé dans des applications d'ingénierie tissulaire ou de la chirurgie des tissus mous, ainsi que les échafaudages produits et un kit associé. Le procédé comprend une première étape de séchage rapide consistant à appliquer une compression mécanique sur une couche de gel polymère et une seconde étape de séchage lent du gel jusqu'à atteindre une fraction de masse polymère d'au moins 60 % p/p dans l'échafaudage final. Le procédé permet la production d'échafaudages présentant des propriétés de régénération et de cicatrisation élevées d'un tissu greffé par l'intermédiaire de l'invasion et de la colonisation des cellules hôtes, ainsi qu'une bonne aptitude à la suture. Ces objectifs sont atteints par la formation à l'intérieur de l'échafaudage d'une architecture non uniforme créant des zones plus souples et plus rigides, qui est maintenue même lors du re-gonflement de l'échafaudage après l'hydratation du produit final séché.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)