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1. (WO2017178577) MEDICAL APPLICATION OF RESMINOSTAT IN ASIAN PATIENTS
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Pub. No.: WO/2017/178577 International Application No.: PCT/EP2017/058902
Publication Date: 19.10.2017 International Filing Date: 13.04.2017
IPC:
A61K 45/06 (2006.01) ,A61K 31/40 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
Applicants:
4SC AG [DE/DE]; Fraunhoferstraße 22 82152 Planegg-Martinsried, DE
Inventors:
GRÖPPEL, Manfred; DE
Agent:
BOEHMERT & BOEHMERT; Hollerallee 32 28209 Bremen, DE
Priority Data:
16165258.114.04.2016EP
Title (EN) MEDICAL APPLICATION OF RESMINOSTAT IN ASIAN PATIENTS
(FR) APPLICATION MÉDICALE DE RESMINOSTAT CHEZ DES PATIENTS ASIATIQUES
Abstract:
(EN) The invention relates to medical applications of the HDAC inhibitor resminostat ((E)-3-[1-{4-Dimethylaminomethyl-benzenesulfonyl)-1H-pyrroi-3-yl]-N-hydroxy-acrylamide) or a salt or solvate thereof in the treatment of benign or malignant neoplasia in a human subject, wherein said human subject is an Asian, and wherein said treatment comprises administering resminostat or a salt or solvate thereof to said human subiect in a daily dose of less than 600 mg resminostat, and administering at least one further chemotherapeutic agent to said human subject.
(FR) L'invention concerne des applications médicales de l'inhibiteur de HDAC resminostat ((E)-3-[1- {4-diméthylaminométhyl-benzènesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide) ou un sel ou un solvate de ce dernier dans le traitement d'une néoplasie bénigne ou maligne chez un sujet humain, ledit sujet humain étant un sujet asiatique, et ledit traitement comprenant l'administration de resminostat ou d'un sel ou d'un solvate de ce dernier audit sujet humain à une dose quotidienne inférieure à 600 mg de resminostat, et l'administration d'au moins un autre agent chimiothérapeutique audit sujet humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)