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1. (WO2017177991) BLOCK COPOLYMER FOR OVERCOMING DRUG RESISTANCE OF TUMOURS TO CHEMOTHERAPY, ITS POLYMER-DRUG CONJUGATE, PHARMACEUTICAL COMPOSITION CONTAINING THEM, METHOD OF PREPARATION AND USE THEREOF
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Pub. No.:    WO/2017/177991    International Application No.:    PCT/CZ2017/050015
Publication Date: 19.10.2017 International Filing Date: 10.04.2017
IPC:
A61K 47/60 (2017.01), A61K 47/58 (2017.01), A61K 47/65 (2017.01), A61K 47/69 (2017.01), A61K 9/107 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I. [CZ/CZ]; Heyrovskeho namesti 2 16206 Praha 6 - Brevnov (CZ).
MIKROBIOLOGICKY USTAV AV CR, V.V.I. [CZ/CZ]; Videnska 1083 14220 Praha 4 (CZ)
Inventors: ETRYCH, Tomas; (CZ).
KOSTKA, Libor; (CZ).
BRAUNOVA, Alena; (CZ).
CUCHALOVA, Lucie; (CZ).
SIROVA, Milada; (CZ).
JANOUSKOVA, Olga; (CZ)
Agent: HARTVICHOVA, Katerina; (CZ)
Priority Data:
PV 2016-206 11.04.2016 CZ
Title (EN) BLOCK COPOLYMER FOR OVERCOMING DRUG RESISTANCE OF TUMOURS TO CHEMOTHERAPY, ITS POLYMER-DRUG CONJUGATE, PHARMACEUTICAL COMPOSITION CONTAINING THEM, METHOD OF PREPARATION AND USE THEREOF
(FR) COPOLYMÈRE SÉQUENCÉ POUR SURMONTER LA PHARMACORÉSISTANCE DE TUMEURS À UNE CHIMIOTHÉRAPIE, SON CONJUGUÉ POLYMÈRE-MÉDICAMENT, COMPOSITION PHARMACEUTIQUE CONTENANT CELUI-CI, PROCÉDÉ DE PRÉPARATION ET UTILISATION DE CELUI-CI
Abstract: front page image
(EN)The present invention relates to a block copolymer for overcoming drug resistance of tumours to chemotherapy, comprising blocks A and B, connected to each other with a hydrolytically, reductively or enzymatically biodegradable linker, wherein the hydrophilic block A is formed by poly(N-(2-hydroxypropyl) methacrylamide), eventually containing comonomers enabling covalent binding of drugs, and the hydrophobic block B is formed by a polypropylene oxide. The invention relates also to a polymer conjugate containing the block copolymer and the low molecular weight drug, to a pharmaceutical composition containing them and to the use thereof in medicine.
(FR)La présente invention concerne un copolymère séquencé pour surmonter la pharmacorésistance de tumeurs à une chimiothérapie, comprenant des blocs A et B, mutuellement reliés par un lieur biodégradable par hydrolyse, réduction ou de façon enzymatique, le bloc hydrophile A étant formé de poly(N-(2-hydroxypropyl)méthacrylamide), contenant finalement des comonomères permettant la liaison covalente de médicaments, et le bloc hydrophobe B est formé de poly(oxyde de propylène). L'invention concerne en outre un conjugué de polymère contenant le copolymère séquencé et le médicament de faible poids moléculaire, une composition pharmaceutique contenant ceux-ci et leur utilisation en médecine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Czech (CS)