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1. (WO2017177837) HETEROCYCLIC-SUBSTITUTED PYRIDINOPYRIMIDINONE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF

Pub. No.:    WO/2017/177837    International Application No.:    PCT/CN2017/078935
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Sat Apr 01 01:59:59 CEST 2017
IPC: C07D 498/04
C07D 498/10
C07D 513/04
A61P 35/00
A61P 35/02
Applicants: SHANGHAI XUNHE PHARMACEUTICAL TECHNOLOGY CO., LTD.
上海勋和医药科技有限公司
Inventors: ZHENG, Yongyong
郑永勇
JIN, Hua
金华
ZHOU, Feng
周峰
HUANG, Meihua
黄美花
MENG, Xin
孟欣
Title: HETEROCYCLIC-SUBSTITUTED PYRIDINOPYRIMIDINONE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF
Abstract:
The present invention relates to a heterocyclic-substituted pyridinopyrimidinone derivative, and the use thereof as a therapeutically effective cyclin-dependent kinase (CDK) inhibitor. In particular, the present invention relates to the use of a new heterocyclic-substitute pyridinopyrimidinone derivative as shown in formula (I) and a pharmaceutical composition thereof as a selective CDK4/6 inhibitor in preventing or treating diseases related to CDK4/6.