Search International and National Patent Collections

1. (WO2017177668) ZIYUGLYCOSIDE II POLYMER MICELLE AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2017/177668    International Application No.:    PCT/CN2016/104876
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Tue Nov 08 00:59:59 CET 2016
IPC: A61K 9/14
A61K 31/704
A61P 7/00
Applicants: SICHUAN INLU WEITE PHARMACEUTICAL TECHNOLOGY CO., LTD.
四川英路维特医药科技有限公司
Inventors: YANG, Shilin
杨世林
Title: ZIYUGLYCOSIDE II POLYMER MICELLE AND PREPARATION METHOD THEREFOR
Abstract:
A ziyuglycoside II polymer micelle, prepared by the following raw material and excipient in parts by weight: 20 parts of ziyuglycoside II, and 100-5000 parts of mPEG-PLA-Phe(Boc). Quality assessment experiments indicate that the prepared ziyuglycoside II polymer micelle has the best quality only when mPEG-PLA-Phe(Boc) is used as the carrier material, and use of other materials would cause degradation of the preparation quality. In pharmacological experiments, compared with the model group, the ziyuglycoside II micelle can significantly increase the amounts of WBC, RBC, PLT, NEUT, and HGB in peripheral blood, and the effect of the ziyuglycoside II micelle is obviously better than a ziyuglycoside II crude drug. It indicates that the ziyuglycoside II polymer micelle has good therapeutic and/or preventive effects for bone marrow suppression, and can improve the bioavailability of ziyuglycoside II, which is a poorly soluble drug.