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1. (WO2017177307) BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/177307    International Application No.:    PCT/CA2017/000083
Publication Date: 19.10.2017 International Filing Date: 18.04.2017
IPC:
C07C 317/16 (2006.01), A61K 31/09 (2006.01), A61K 31/10 (2006.01), A61K 31/165 (2006.01), A61K 31/222 (2006.01), A61K 31/4164 (2006.01), A61P 35/00 (2006.01), C07C 311/04 (2006.01), C07C 317/22 (2006.01), C07C 43/23 (2006.01), C07D 233/60 (2006.01), C07D 295/088 (2006.01)
Applicants: BRITISH COLUMBIA CANCER AGENCY BRANCH [CA/CA]; 600 West 10th Avenue Vancouver, British Columbia V5Z 4E6 (CA).
THE UNIVERSITY OF BRITISH COLUMBIA UNIVERSITY-INDUSTRY LIAISON OFFICE [CA/CA]; #103-6190 Agronomy Road Vancouver, British Columbia V6T 1Z3 (CA)
Inventors: ANDERSEN, Raymond; (CA).
SADAR, Marianne Dorothy; (CA).
JlAN, Kunzhong; (CA).
MAWJl, Nasrin R.; (CA).
WANG, Jun; (CA).
BANUELOS, Carmen Adriana; (CA).
YANG, Yu-Chi; (CA)
Agent: DEETH WILLIAMS WALL LLP; 150 York Street; Suite 400 Toronto, Ontario M5H 3S5 (CA)
Priority Data:
62/323,196 15.04.2016 US
Title (EN) BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
(FR) DÉRIVÉS DE BISPHÉNOL ET LEUR UTILISATION EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU RÉCEPTEUR DES ANDROGÈNES
Abstract: front page image
(EN)Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
(FR)Cette invention concerne des composés ayant une structure de Formule I ou un sel pharmaceutiquement acceptable, un tautomère ou un stéréoisomère de ceux-ci, où R1, R2, R3, R11a, R11b, R11c, R11d, et X, étant tels que définis dans la présente invention. Les utilisations de ces composés pour moduler l'activité du récepteur des androgènes, imager des diagnostics dans le domaine du cancer et des substances thérapeutiques, et des méthodes destinées à traiter des sujets en ayant besoin, dont des sujets atteints du cancer de la prostate sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)