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1. (WO2017177169) MULTIMERIC CODING NUCLEIC ACID AND USES THEREOF

Pub. No.:    WO/2017/177169    International Application No.:    PCT/US2017/026660
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Sat Apr 08 01:59:59 CEST 2017
IPC: C12N 15/09
A61K 31/7115
A61K 31/7125
C07H 21/02
C12N 15/11
Applicants: TRANSLATE BIO, INC.
Inventors: DEROSA, Frank
HEARTLEIN, Michael
CRAWFORD, Daniel
KARVE, Shrirang
Title: MULTIMERIC CODING NUCLEIC ACID AND USES THEREOF
Abstract:
The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use. In some embodiments, a multimeric coding nucleic acid (MCNA) comprises two or more encoding polynucleotides linked via 3' ends such that the multimeric coding nucleic acid compound comprises two or more 5' ends.