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1. (WO2017177142) MRSA BIOFILM INHIBITION
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Pub. No.: WO/2017/177142 International Application No.: PCT/US2017/026608
Publication Date: 12.10.2017 International Filing Date: 07.04.2017
IPC:
A61K 31/496 (2006.01) ,A61K 31/70 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
Applicants:
UNIVERSITY OF SOUTH FLORIDA [US/US]; 3802 Spectrum Blvd. Suite 100 Tampa, Florida 33612, US
UAB RESEARCH FOUNDATION [US/US]; 701 20th Street South 770 Administration Building Birmingham, Alabama 36294-0107, US
Inventors:
BAKER, Bill, J.; US
SHAW, Lindsey, N.; US
MCCLINTOCK, James, Bruce; US
AMSLER, Charles, D.; US
FRIES, Jacqueline, Lee; US
WITKOWSKI, Christopher, G.; US
FLEEMAN, Renee, M.; US
Agent:
HOFMEISTER, Todd, S.; US
SMITH, Billie Jean; US
YAN, Wei; US
Priority Data:
62/319,66107.04.2016US
Title (EN) MRSA BIOFILM INHIBITION
(FR) INHIBITION DE BIOFILM DE SARM
Abstract:
(EN) Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistant Staphylococcus aureus biofilm infection.
(FR) L'invention concerne un composé de darwinolide ayant un squelette de carbone précédemment non décrit et sa forme cristalline. L'invention concerne également des procédés d'isolement de darwinolide, des compositions comprenant du darwinolide, et des procédés de traitement d'une infection, telle qu'une infection par un biofilm de Staphylococcusaureus résistant à la méthicilline.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)