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1. (WO2017177135) INNATE METABOLIC IMAGING OF CELLULAR SYSTEMS

Pub. No.:    WO/2017/177135    International Application No.:    PCT/US2017/026600
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Sat Apr 08 01:59:59 CEST 2017
IPC: G01C 21/00
G06T 7/00
G06T 7/11
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: LEFTIN, Avigdor
KOUTCHER, Jason
Title: INNATE METABOLIC IMAGING OF CELLULAR SYSTEMS
Abstract:
Described herein are systems and methods for image-based (e.g., MRI-based) spatial and temporal mapping of macrophages and other cell types, without the need for image contrast agents. These systems and methods are particularly useful for imaging macrophages because they naturally store metabolites, such as iron. Alternatively, the systems and methods described herein can be used where contrast agents are administered, rather than looking only at endogenous metabolite deposits.