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1. (WO2017177029) COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION AND VIRAL REPLICATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/177029    International Application No.:    PCT/US2017/026391
Publication Date: 12.10.2017 International Filing Date: 06.04.2017
IPC:
C12Q 1/68 (2006.01), C12N 15/10 (2006.01), C12N 15/11 (2006.01), C07K 14/47 (2006.01)
Applicants: DUKE UNIVERSITY [US/US]; 2812 Erwin Road Durham, NC 27705 (US)
Inventors: CULLEN, Bryan, R.; (US).
KENNEDY, E., Matthew; (US).
BOGERD, Hal, P.; (US).
KORNEPATI, Anand; (US).
HEATON, Nicholas; (US).
COURTNEY, David; (US)
Agent: VANHEYNINGEN, Tambryn, K.; (US).
WILLIAMS, Edward, R.; (US).
ESSMANN, Gary, A.; (US).
SOLVESON, George, H.; (US).
TAKEN, Michael, E.; (US)
Priority Data:
62/318,868 06.04.2016 US
62/361,282 12.07.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION AND VIRAL REPLICATION
(FR) COMPOSITIONS ET MÉTHODES POUR AMÉLIORER L'EXPRESSION GÉNIQUE ET LA RÉPLICATION VIRALE
Abstract: front page image
(EN)The invention generally relates to compositions (including polynucleotides, constructs, fusion proteins, vectors, and cells) and methods of using such compositions for enhancing gene expression, protein production and viral replication. More specifically, the invention relates to use of m6A sequences and/or YTHDF polypeptides to enhance gene expression or viral replication.
(FR)L'invention concerne généralement des compositions (y compris des polynucléotides, des constructions, des protéines de fusion, des vecteurs et des cellules) et des méthodes d'utilisation de telles compositions pour améliorer l'expression génique, la production de protéines et la réplication virale. Plus spécifiquement, l'invention concerne l'utilisation de séquences m6A et/ou de polypeptides YTHDF pour améliorer l'expression génique ou la réplication virale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)