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1. (WO2017176999) GLYCOSYLATED OLIGONUCLEOTIDES THAT MIMIC THE HIV-1 EPITOPE OF NEUTRAULIZING MONOCLONAL ANTIBODY 2G12

Pub. No.:    WO/2017/176999    International Application No.:    PCT/US2017/026354
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Fri Apr 07 01:59:59 CEST 2017
IPC: C07H 15/22
C07H 21/04
C12N 15/10
C12N 15/117
G01N 33/53
C12P 19/34
Applicants: BRANDEIS UNIVERSITY
Inventors: KRAUSS, Isaac, J.
TEMME, Joel, Sebastian
Title: GLYCOSYLATED OLIGONUCLEOTIDES THAT MIMIC THE HIV-1 EPITOPE OF NEUTRAULIZING MONOCLONAL ANTIBODY 2G12
Abstract:
Disclosed are oligonucleotides that binds specifically to HIV neutralizing monoclonal antibody 2G12 with a K4 value lower than 20 nM, the oligonucleotide comprising a predicted structure, at 37°C, having exactly one stem-loop whereby the loop comprises the nucleotide sequence of AACCNACGGANAAA (SEQ ID NO: 1), where N is a modified nucleoside base, and the stem includes at least 3 nucleotide base-pairs and one of the nucleotides in the stem includes a modified nucleoside base, wherein the modified nucleoside base has the structure— B— L— A where A is a branched-chain Man9 oligosaccharide, L is a linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. Various method of using the oligonucleotides, immunogenic conjugates, and pharmaceutical compositions are also disclosed.