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1. (WO2017176999) GLYCOSYLATED OLIGONUCLEOTIDES THAT MIMIC THE HIV-1 EPITOPE OF NEUTRAULIZING MONOCLONAL ANTIBODY 2G12
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/176999    International Application No.:    PCT/US2017/026354
Publication Date: 12.10.2017 International Filing Date: 06.04.2017
IPC:
C07H 15/22 (2006.01), C07H 21/04 (2006.01), C12N 15/10 (2006.01), C12N 15/117 (2010.01), G01N 33/53 (2006.01), C12P 19/34 (2006.01)
Applicants: BRANDEIS UNIVERSITY [US/US]; 415 South Street Waltham, MA 02454 (US)
Inventors: KRAUSS, Isaac, J.; (US).
TEMME, Joel, Sebastian; (US)
Agent: MERKEL, Edwin, V.; (US).
TISCHNER, Tate, L.; (US).
EVANS, Georgia; (US).
MERKEL, Edwin, V.; (US).
LEINBERG, Gunnar, G.; (US)
Priority Data:
62/319,763 07.04.2016 US
Title (EN) GLYCOSYLATED OLIGONUCLEOTIDES THAT MIMIC THE HIV-1 EPITOPE OF NEUTRAULIZING MONOCLONAL ANTIBODY 2G12
(FR) OLIGONUCLÉOTIDES GLYCOSYLÉS IMITANT L'ÉPITOPE DU VIH-1 DE L'ANTICORPS MONOCLONAL 2G12 NEUTRALISANT
Abstract: front page image
(EN)Disclosed are oligonucleotides that binds specifically to HIV neutralizing monoclonal antibody 2G12 with a K4 value lower than 20 nM, the oligonucleotide comprising a predicted structure, at 37°C, having exactly one stem-loop whereby the loop comprises the nucleotide sequence of AACCNACGGANAAA (SEQ ID NO: 1), where N is a modified nucleoside base, and the stem includes at least 3 nucleotide base-pairs and one of the nucleotides in the stem includes a modified nucleoside base, wherein the modified nucleoside base has the structure— B— L— A where A is a branched-chain Man9 oligosaccharide, L is a linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. Various method of using the oligonucleotides, immunogenic conjugates, and pharmaceutical compositions are also disclosed.
(FR)L'invention concerne des oligonucléotides qui se lient spécifiquement à l'anticorps monoclonal neutralisant le VIH 2G12 avec une valeur K4 inférieure à 20 nM, l'oligonucléotide comprenant une structure prédite, à 37 °C, ayant exactement une boucle-tige, la boucle comprenant la séquence nucléotidique de AACCNACGGANAAA (SEQ ID n° 1), N étant une base nucléosidique modifiée, et la tige comprenant au moins trois paires de bases nucléotidiques et l'un des nucléotides dans la tige comprenant une base nucléosidique modifiée, la base nucléosidique modifiée ayant la structure — B— L— A où A est un oligosaccharide de Man9 à chaîne ramifiée, L est une molécule de liaison, et B est indépendamment une base pyrimidine ou pyridine liée au squelette sucre-phosphate de l'oligonucléotide. L'invention porte en outre sur des conjugués immunogènes qui incluent ledit oligonucléotide, et sur des compositions pharmaceutiques qui incluent ledit oligonucléotide ou lesdits conjugués immunogènes. L'invention concerne également divers procédés d'utilisation des oligonucléotides, des conjugués immunogènes et des compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)