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1. (WO2017176958) MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/176958    International Application No.:    PCT/US2017/026275
Publication Date: 12.10.2017 International Filing Date: 06.04.2017
IPC:
C07D 487/10 (2006.01), C07D 401/04 (2006.01), A61K 31/4745 (2006.01), A61P 35/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office Of Technology Transfer 1600 Huron Parkway, 2nd Floor Ann Arbor, MI 48109-2590 (US)
Inventors: WANG, Shaomeng; (US).
LI, Yangbing; (US).
AGUILAR, Angelo; (US).
ZHOU, Bing; (CN).
HU, Jiantao; (US).
XU, Fuming; (US).
QIN, Chong; (US).
HU, Yang; (US).
XIANG, Weiguo; (US).
REJ, Rohan; (US).
YANG, Jiuling; (US).
HAN, Xin; (US).
BAI, Longchuan; (US).
YANG, Chao-Yie; (US)
Agent: NAPOLI, James, J.; (US)
Priority Data:
62/409,571 18.10.2016 US
62/393,888 13.09.2016 US
62/318,974 06.04.2016 US
62/409,592 18.10.2016 US
62/321,499 12.04.2016 US
62/393,935 13.09.2016 US
62/393,874 13.09.2016 US
Title (EN) MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION
(FR) INTERMÉDIAIRES MONOFONCTIONNELS POUR LA DÉGRADATION D'UNE PROTÉINE CIBLE DÉPENDANTE DU LIGAND
Abstract: front page image
(EN)The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
(FR)La présente invention concerne des composés représentés par la formule I : et les sels ou solvates de ceux-ci, où X, L, Y et B sont tels que définis dans la description. Les composés de formule I sont des immunomodulateurs et/ou des intermédiaires synthétiques monofonctionnels qui peuvent être utilisés pour préparer des conjugués de médicaments à petites molécules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)