Search International and National Patent Collections

1. (WO2017176946) SYSTEMS AND METHODS FOR TARGETED THERAPY BASED ON SINGLE-CELL STIMULUS PERTURBATION RESPONSE

Pub. No.:    WO/2017/176946    International Application No.:    PCT/US2017/026243
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Thu Apr 06 01:59:59 CEST 2017
IPC: G06F 19/18
G06F 17/30
G01N 33/48
G06F 19/20
H01J 49/00
H01J 49/40
B01D 59/44
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: ANCHANG, Benedict
PLEVRITIS, Sylvia, K.
Title: SYSTEMS AND METHODS FOR TARGETED THERAPY BASED ON SINGLE-CELL STIMULUS PERTURBATION RESPONSE
Abstract:
Systems and methods for targeted therapy based on single-cell stimulus perturbation response. In one embodiment, a method for optimizing stimulus combinations for therapy includes receiving a cell sample, treating the cell sample with a plurality of stimuli by treating a different portion of the cell sample with one of the plurality of stimuli for each of the plurality of stimuli, labeling the cell sample with a plurality of metal-conjugated probes, analyzing the cell sample using a mass spectrometer, obtaining mass spectrometry data from the mass spectrometer, identifying subpopulations within the cell sample using the mass spectrometry data, computing stimulus effects, generating a nested-effects model using the mass spectrometry data, and scoring stimuli combinations using the computing device, wherein the stimulus combinations are combinations made from the plurality of stimuli.