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1. (WO2017176929) COMPOSITIONS AND METHODS FOR SELECTIVE INHIBITION OF GRAINYHEAD-LIKE PROTEIN EXPRESSION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/176929    International Application No.:    PCT/US2017/026217
Publication Date: 12.10.2017 International Filing Date: 05.04.2017
IPC:
C12N 15/113 (2010.01), C12N 15/861 (2006.01), C12N 15/86 (2006.01), C12N 15/85 (2006.01), A61K 31/7105 (2006.01), A61K 31/713 (2006.01), A61K 48/00 (2006.01), A61K 47/42 (2017.01), A61P 1/16 (2006.01)
Applicants: UNIVERSITY OF MASSACHUSETTS [US/US]; 225 Franklin Street Boston, MA 02110 (US)
Inventors: SZABO, Gyongyi; (US).
GAO, Guangping; (US).
SATISHCHANDRAN, Abhishek; (US)
Agent: YOUNG, Daniel; (US)
Priority Data:
62/400,583 27.09.2016 US
62/319,169 06.04.2016 US
62/318,728 05.04.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR SELECTIVE INHIBITION OF GRAINYHEAD-LIKE PROTEIN EXPRESSION
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'INHIBITION SÉLECTIVE DE L'EXPRESSION D'UNE PROTÉINE DE TYPE GRAINHEAD
Abstract: front page image
(EN)In some aspects, the disclosure relates to methods and compositions for modulation of miR- 122 expression in a cell or a subject. In some embodiments, methods and compositions described by the disclosure are useful for the treatment of liver-associated diseases (e.g., chronic liver disease, alcoholic liver disease).
(FR)Selon certains aspects, la présente divulgation concerne des procédés et des compositions pour moduler l'expression de miR-122 dans une cellule ou chez un sujet. Dans certains modes de réalisation, les procédés et les compositions décrits par la présente divulgation sont utiles pour le traitement de maladies associées au foie (p. ex., maladie hépatique chronique, maladie alcoolique du foie).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)