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1. (WO2017176864) COMPOSITIONS FOR AND METHODS OF ENRICHING GENETIC MUTANTS FOR DETECTING, DIAGNOSING, AND PROGNOSING CANCER
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Pub. No.: WO/2017/176864 International Application No.: PCT/US2017/026110
Publication Date: 12.10.2017 International Filing Date: 05.04.2017
IPC:
C12Q 1/68 (2006.01) ,C12N 15/63 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants: LARIAT BIOSCIENCES, INC.[US/US]; 100 Cummings Center, Suite 438N Beverly, MA 01915, US
Inventors: LARSON, Jonathan, W.; US
Agent: RUSSELL, Hathaway, P.; US
BLOUNT, Jennifer, V.; US
AKHIEZER, Alexander; US
CHOI, Philip, S.; US
ABELLEIRA, Susan, M.; US
Priority Data:
62/318,53205.04.2016US
Title (EN) COMPOSITIONS FOR AND METHODS OF ENRICHING GENETIC MUTANTS FOR DETECTING, DIAGNOSING, AND PROGNOSING CANCER
(FR) COMPOSITIONS ET PROCÉDÉS D’ENRICHISSEMENT DE MUTANTS GÉNÉTIQUES AUX FINS DE DÉTECTION, DIAGNOSTIC, ET PROGNOSTIC DU CANCER
Abstract:
(EN) Compositions for detecting, diagnosing and prognosing cancer in individuals having or suspected of having cancer are provided. Said compositions are used to enrich a nucleic acid target comprising a locus of genetic variation, e.g., single nucleotide polymorphism (SNPs) and variable mutations, such as small insertions, deletions, and replacements ("indels") within a sample for ease and improved detection. In addition, kits are provided for measuring levels or the presence of SNPs and indels associated with cancer for detecting, diagnosing and prognosing cancer. Furthermore, methods are provided for detecting, diagnosing and prognosing cancer in individuals having or suspected of having cancer comprising determining the enrichment levels and/or presence or absence of the SNPs and indels in a subject.
(FR) La présente invention décrit des compositions de détection, diagnostic et pronostic du cancer chez des personnes présentant ou étant suspectées d’avoir un cancer. Lesdites compositions sont utilisées pour enrichir une cible acide nucléique comprenant un locus de variation génétique, par exemple, polymorphisme à nucléotide unique (SNP) et mutations variables, telles que de petites insertions, délétions, et remplacements ("indels") au sein d’un échantillon pour une détection facilitée et améliorée. De plus, des trousses sont prévues afin de mesurer les niveaux ou la présence des SNP et des indels associés au cancer dans le but de détecter, de diagnostiquer et de pronostiquer le cancer. En outre, des procédés sont prévus aux fins de détection, diagnostic, et pronostic du cancer chez des individus présentant ou étant suspectés de présenter un cancer comprenant la détermination des niveaux d’enrichissement et/ou de la présence ou de l’absence des SNP et des indels chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)