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1. (WO2017176807) COMPOSITIONS FOR INHIBITING FORMATION OF AND/OR DISRUPTING BACTERIAL BIOFILMS AND METHODS OF USE THEREFOR
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Pub. No.: WO/2017/176807 International Application No.: PCT/US2017/026012
Publication Date: 12.10.2017 International Filing Date: 04.04.2017
IPC:
A61K 39/02 (2006.01) ,A61K 39/40 (2006.01) ,A61K 35/74 (2015.01) ,A61K 38/16 (2006.01) ,A61K 39/395 (2006.01) ,A61K 31/7076 (2006.01) ,C12N 15/03 (2006.01) ,C12N 15/10 (2006.01) ,A61F 2/02 (2006.01)
Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION[US/US]; 250 West Main Street, Suite 300 Charlottesville, VA 22902, US
Inventors: HEWLETT, Erik, L.; US
HOFFMAN, Casandra, L.; US
Agent: TAYLOR, JR., Arles, A.; US
Priority Data:
62/318,15804.04.2016US
Title (EN) COMPOSITIONS FOR INHIBITING FORMATION OF AND/OR DISRUPTING BACTERIAL BIOFILMS AND METHODS OF USE THEREFOR
(FR) COMPOSITIONS POUR INHIBER LA FORMATION ET/OU INTERROMPRE LES BIOFILMS BACTÉRIENS ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Abstract: front page image
(EN) Provided are compositions that include an effective amount of a peptide or polypeptide derived from a Bordetella ACT AC domain, optionally wherein the peptide or polypeptide is 80-100% identical to an amino acid sequence as set forth in SEQ ID NOs: 1 -5 and 44-53. Also provided are methods of using the same for preventing and/or treating a diseases, disorders, and conditions associated with the presence and/or development of biofilm; and for reducing the incidence of nosocomial infections; for inhibiting biofilm development and/or for reducing or eliminating biofilm present on medical, dental, and industrial surfaces.
(FR) L'invention concerne des compositions qui comprennent une quantité efficace d'un peptide ou d'un polypeptide dérivé d'un domaine AC de Bordetella ACT, facultativement le peptide ou le polypeptide étant identique à 80-100 % à une séquence d'acides aminés telle que définie dans SEQ ID n° 1 à 5 et 44 à 53. L'invention concerne également des procédés d'utilisation de celles-ci pour prévenir et/ou traiter des maladies, des troubles et des états associés à la présence et/ou au développement d'un biofilm ; et pour réduire l'incidence d'infections nosocomiales ; pour inhiber le développement de biofilm et/ou pour réduire ou éliminer un biofilm présent sur des surfaces médicales, dentaires et industrielles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)