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1. (WO2017176770) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY
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Pub. No.: WO/2017/176770 International Application No.: PCT/US2017/025964
Publication Date: 12.10.2017 International Filing Date: 04.04.2017
IPC:
C07C 235/00 (2006.01) ,C07C 235/20 (2006.01)
Applicants: THE SCHEPENS EYE RESEARCH INSTITUTE, INC.[US/US]; 20 Staniford Street Boston, MA 02114, US
Inventors: NG, Yin Shan, Eric; US
GNANAGURU, Gopalan; US
MACKEY, Ashley; US
D'AMORE, Patricia, A.; US
Agent: BEATTIE, Ingrid, A.; US
BAUER, John, A.; US
AZRIN, Linda, B.; US
ADAMS, Lisa; US
AMENDT, Kevin, C.; US
Priority Data:
62/318,16504.04.2016US
Title (EN) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY
(FR) AGONISTES SÉLECTIFS DES RÉCEPTEURS GAMMA ACTIVÉS PAR LES PROLIFÉRATEURS DE PEROXYSOMES POUR INHIBER LA DÉGÉNÉRESCENCE DE L'ÉPITHÉLIUM PIGMENTAIRE RÉTINIEN OU L'ATROPHIE GÉOGRAPHIQUE
Abstract: front page image
(EN) The invention provides a solution to the clinical problem of retinal pigment epithelium (RPE) degeneration or geographic atrophy (GA) associated with AMD. PPARϒ selective agonists, e.g., troglitazone and analogs thereof are used to reduce or inhibit RPE degeneration, GA, and/or the progression of dry AMD.
(FR) L'invention apporte une solution au problème clinique de la dégénérescence de l'épithélium pigmentaire rétinien (EPR) ou de l'atrophie géographique (AG) associée à la DMLA. Des agonistes sélectifs des PPARϒ, p. ex., troglitazone et analogues de celle-ci, sont utilisés pour réduire ou inhiber la dégénérescence de l'EPR, l'AG, et/ou l'évolution de la DMLA sèche.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)