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1. (WO2017176336) COMPOSITIONS AND METHODS FOR THE TREATMENT OF WOUNDS, DISORDERS, AND DISEASES OF THE SKIN
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/176336 International Application No.: PCT/US2016/068974
Publication Date: 12.10.2017 International Filing Date: 28.12.2016
IPC:
C12N 15/869 (2006.01) ,C07K 14/78 (2006.01) ,A61K 48/00 (2006.01) ,A61K 38/39 (2006.01) ,A61P 17/00 (2006.01) ,C07K 19/00 (2006.01) ,C12N 9/02 (2006.01) ,C07K 14/47 (2006.01)
Applicants: KRYSTAL BIOTECH, INC.[US/US]; 2100 Wharton Street, Suite 701 Pittsburgh, PA 15203, US
Inventors: KRISHNAN, Suma; US
AGARWAL, Pooja; US
Agent: TSAO, Patricia; US
BANKO, Max; US
AMII, Lisa, A.; US
ARJOMAND, Mehran; US
BASOL, Erol, C.; US
Priority Data:
62/320,31608.04.2016US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT OF WOUNDS, DISORDERS, AND DISEASES OF THE SKIN
(FR) COMPOSITIONS ET PROCÉDÉS DESTINÉS AU TRAITEMENT DES PLAIES, DES TROUBLES, ET DES MALADIES DE LA PEAU
Abstract: front page image
(EN) The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha- 1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.
(FR) La présente invention décrit, en partie, des compositions pharmaceutiques comprenant un ou plusieurs polynucléotides appropriés pour améliorer, accroître, augmenter, et/ou enrichir les niveaux de polypeptide de la chaîne alpha-1 (VII) du collagène et/ou du polypeptide de la lysyl hydroxylase 3 et/ou du polypeptide du cytosquelette de type I de la kératine 17 chez un sujet. La présente invention décrit également, en partie, des compositions et des procédés pharmaceutiques à utiliser pour fournir une prophylaxie, un effet palliatif, ou un soulagement thérapeutique à une plaie, un trouble, ou une maladie de la peau chez un sujet, comprenant un sujet atteint, ou présentant un risque de développer, un ou plusieurs symptômes d’épidermolyse bulleuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)