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|1. (WO2017175072) PEPTIDE SHUTTLE BASED GENE DISRUPTION|
|Applicants:||FELDAN BIO INC.
|Title:||PEPTIDE SHUTTLE BASED GENE DISRUPTION|
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells. More specifically, the present description relates to synthetic peptides and polypeptide-based shuttle agents comprising an endosome leakage domain (ELD) operably linked to a cell penetrating domain (CPD), or an ELD operably linked to a histidine-rich domain and a CPD. Compositions, kits, methods and uses relating to same are also described. Methods for using the disclosed polypeptide-based shuttles for delivering a transcription factor and/or nuclease to eukaryotic cell nucleus and uses of the derived cells are also described.