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1. (WO2017175022) METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING MAST CELL DEGRANULATION

Pub. No.:    WO/2017/175022    International Application No.:    PCT/IB2016/000617
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Fri Apr 08 01:59:59 CEST 2016
IPC: C12N 15/113
A61K 31/713
G01N 33/68
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
FONDATION IMAGINE
UNIVERSITÉ PARIS DESCARTES
UNIVERSITÉ PARIS DIDEROT - PARIS 7
Inventors: MENASCHE, Gaël
BLANK, Ulrich
DANELLI, Luca
FISCHER, Alain
KUROWSKA, Mathieu
MUNOZ, Isabelle
Title: METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING MAST CELL DEGRANULATION
Abstract:
The present invention relates to methods and pharmaceutical compositions for inhibiting mast cell degranulation. In particular, the present invention relates to a method of inhibiting mast cell degranulation in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of inhibiting the formation the Kinesin-1/Slp3/Rab27b complex.