Search International and National Patent Collections

1. (WO2017175006) T CELL RECEPTORS

Pub. No.:    WO/2017/175006    International Application No.:    PCT/GB2017/050985
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Sat Apr 08 01:59:59 CEST 2017
IPC: C07K 14/725
Applicants: IMMUNOCORE LIMITED
Inventors: HAYES, Conor
HIBBERT, Linda
LIDDY, Nathaniel
MAHON, Tara
RAMAN, Marine
Title: T CELL RECEPTORS
Abstract:
The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the germline cancer antigen MAGE A4. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGE A4 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.