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1. (WO2017174995) KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/174995    International Application No.:    PCT/GB2017/050970
Publication Date: 12.10.2017 International Filing Date: 06.04.2017
IPC:
C07D 403/12 (2006.01), A61K 31/44 (2006.01), A61K 31/506 (2006.01), C07D 213/74 (2006.01), C07D 401/12 (2006.01), C07D 405/12 (2006.01), C07D 239/47 (2006.01), C07D 409/12 (2006.01), C07D 413/12 (2006.01), A61P 29/00 (2006.01)
Applicants: RESPIVERT LIMITED [GB/GB]; 50-100 Holmers Farm Way High Wycombe Buckinghamshire HP12 4EG (GB).
TOPIVERT PHARMA LIMITED [GB/GB]; 265 Strand London WC2R 1BH (GB)
Inventors: FYFE, Matthew Colin Thor; (GB).
THOM, Stephen Malcolm; (GB)
Agent: OWEN, Deborah; (GB)
Priority Data:
1605844.8 06.04.2016 GB
Title (EN) KINASE INHIBITORS
(FR) INHIBITEURS DE KINASE
Abstract: front page image
(EN)There are provided compounds of formula I, (I) wherein T, A, Q, Z, G, R4, R5a, R5b and n have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
(FR)L'invention concerne des composés représentés par la formule I, (I) dans laquelle T, A, Q, Z, G, R4, R5a à R5b et n ont les significations données dans la description, ces composés ayant une activité anti-inflammatoire (p. ex., par inhibition d'un ou de plusieurs des éléments de la famille des enzymes de protéine kinase activées par le mitogène p38 ; la kinase Syk ; et des éléments de la famille Src des tyrosines kinases) et ayant un intérêt thérapeutique, y compris dans des combinaisons pharmaceutiques, en particulier dans le traitement de maladies inflammatoires, y compris des maladies inflammatoires du poumon, de l’œil et des intestins.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)