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Pub. No.: WO/2017/174824 International Application No.: PCT/EP2017/058580
Publication Date: 12.10.2017 International Filing Date: 10.04.2017
Chapter 2 Demand Filed: 08.02.2018
IPC:
C07K 14/725 (2006.01) ,C07K 14/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants: ADAPTIMMUNE LIMITED[GB/GB]; 101 Park Drive Milton Park Abingdon Oxfordshire OX14 4RY, GB
Inventors: TRIBBLE, Nicholas; GB
LAWRANCE, William; GB
BAGG, Eleanor; GB
Agent: BIRTLE, Zoe; GB
Priority Data:
1606177.208.04.2016GB
Title (EN) T CELL RECEPTORS
(FR) RÉCEPTEURS DES LYMPHOCYTES T
Abstract:
(EN) The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.
(FR) La présente invention concerne des récepteurs des lymphocytes T (TCR) qui se lient au peptide restreint HLA-A*0201 GVYDGREHTV (SEQ ID NO : 1) dérivé de la protéine MAGE-A4. Les récepteurs de lymphocytes T selon l'invention présentent d'excellents profils de spécificité vis-à-vis de cet épitope MAGE. L'invention concerne également des acides nucléiques codant pour les récepteurs des lymphocytes T, des cellules modifiées pour présenter les récepteurs des lymphocytes T, des cellules hébergeant des vecteurs d'expression codant pour les récepteurs des lymphocytes T et des compositions pharmaceutiques comprenant les récepteurs des lymphocytes T, des acides nucléiques ou des cellules selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)