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1. WO2017174760 - NOVEL MULTIPLY BACKBONE N-METHYL TRANSFERASES AND USES THEREOF

Publication Number WO/2017/174760
Publication Date 12.10.2017
International Application No. PCT/EP2017/058327
International Filing Date 07.04.2017
IPC
C12N 9/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
CPC
C07K 14/375
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
375from Basidiomycetes
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 2319/21
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
20containing a tag with affinity for a non-protein ligand
21containing a His-tag
C07K 2319/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
50containing protease site
Applicants
  • ETH ZURICH [CH]/[CH]
Inventors
  • AEBI, Markus
  • KÜNZLER, Markus
  • PIEL, Jörn
  • FREEMAN, Michael
  • VAN DER VELDEN, Niels
  • KÄLIN, Noemi
Priority Data
16164245.907.04.2016EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL MULTIPLY BACKBONE N-METHYL TRANSFERASES AND USES THEREOF
(FR) NOUVELLES N-MÉTHYLTRANSFÉRASES À SQUELETTE MULTIPLE ET LEURS UTILISATIONS
Abstract
(EN) The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.
(FR) La présente invention concerne tous les aspects liés à de nouvelles méthyltransférases qui méthylent des amides de (poly)peptides à squelette. La présente invention concerne également des acides nucléiques codant ces enzymes ainsi que des vecteurs correspondants et des cellules hôtes les comprenant. La présente invention concerne par ailleurs l'utilisation desdites enzymes pour modifier des (poly)peptides ainsi que des procédés correspondants. La présente invention concerne en outre de nouvelles enzymes pour modifier des (poly)peptides dérivés du groupe de gènes de l'omphalotine d'O. olearius et les groupes de gènes homologues issus de D. bispora, L. edodes et F. mediterranea ainsi que des aspects associés.
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