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1. (WO2017174610) INTRA-DROPLET SURFACE ENGINEERING TO CAPTURE A MOLECULAR TARGET

Pub. No.:    WO/2017/174610    International Application No.:    PCT/EP2017/058035
Publication Date: Fri Oct 13 01:59:59 CEST 2017 International Filing Date: Wed Apr 05 01:59:59 CEST 2017
IPC: G01N 33/543
Applicants: UNIVERSITE DE STRASBOURG
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIÈRES DE LA CHIMIE
Inventors: WAGNER, Alain
URSUEGUI, Sylvain
RYCKELYNCK, Michaël
PERNOD, Ketty
GRIFFITHS, Andrew, David
Title: INTRA-DROPLET SURFACE ENGINEERING TO CAPTURE A MOLECULAR TARGET
Abstract:
The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary.