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1. (WO2017174580) REAL TIME MONITORING OF PRODUCT PURIFICATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/174580    International Application No.:    PCT/EP2017/057986
Publication Date: 12.10.2017 International Filing Date: 04.04.2017
IPC:
G05B 17/02 (2006.01), G05B 23/02 (2006.01)
Applicants: BOEHRINGER INGELHEIM RCV GMBH & CO KG [AT/AT]; Dr.-Boehringer-Gasse 5-11 1121 Wien (AT).
SANDOZ GMBH [AT/AT]; Biochemiestrasse 10 6250 Kundl (AT)
Inventors: JUNGBAUER, Alois; (AT).
DÜRAUER, Astrid; (AT).
WALCH, Nicole; (AT).
SAUER, Dominik; (AT).
SCHARL-HIRSCH, Theresa; (AT).
MELCHER, Michael; (AT).
LEISCH, Friedrich; (AT)
Agent: WEINZIERL, Gerhard; (DE).
KOCH, Andreas Dr.; (DE).
SCHIWECK, Wolfram Dr.; (DE)
Priority Data:
16163713.7 04.04.2016 EP
Title (EN) REAL TIME MONITORING OF PRODUCT PURIFICATION
(FR) SURVEILLANCE EN TEMPS RÉEL DE PURIFICATION DE PRODUIT
Abstract: front page image
(EN)The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.
(FR)L'invention concerne un procédé et un dispositif qui permettent en temps réel la détermination de la concentration, de la pureté et de la puissance d'un produit biologique pendant des processus de purification et/ou de concentration afin d'intervenir dans le processus, soit pour une régulation de processus, soit pour une libération en temps réel. Les propriétés du flux de traitement sont surveillées en continu par au moins deux capteurs en ligne et à l'aide d'une analyse statistique multivariée de sorte que la concentration, la pureté et la puissance soient déterminées en temps réel.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)