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1. (WO2017174046) A FORMULATION OF IXAZOMIB CITRATE FORM 3
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/174046 International Application No.: PCT/CZ2017/000022
Publication Date: 12.10.2017 International Filing Date: 07.04.2017
IPC:
A61K 9/14 (2006.01) ,A61K 9/48 (2006.01)
Applicants: ZENTIVA, K.S.[CZ/CZ]; U Kabelovny 130 102 37 Praha 10, CZ
Inventors: CERNA, Igor; CZ
SEDMAK, Gregor; CZ
Agent: JIROTKOVA, Ivana; Rott, Ruzicka & Guttmann Vinohradska 37 120 00 Praha 2, CZ
Priority Data:
PV 2016-20408.04.2016CZ
Title (EN) A FORMULATION OF IXAZOMIB CITRATE FORM 3
(FR) FORMULATION DE CITRATE D'IXAZOMIB DE FORME 3
Abstract: front page image
(EN) The invention relates to a pharmaceutical formulation containing ixazomib citrate in crystalline form 3 of formula I, wherein form 3, compared to the hitherto known form 1, is a polymorphically more stable form, which makes it more suitable for a pharmaceutical formulation containing besides ixazomib citrate of form 3 also other acceptable excipients. The pharmaceutical formulation can be in the form of capsules and is packed in a gas-tight AI/AI blister pack to maintain its stability.
(FR) La présente invention concerne une formulation pharmaceutique contenant du citrate d'ixazomib sous forme cristalline 3 de formule I, la forme 3, par comparaison avec la forme 1 connue jusqu'à présent, étant une forme polymorphe plus stable, ce qui la rend plus appropriée pour une formulation pharmaceutique contenant également, en plus du citrate d'ixazomib de forme 3, d'autres excipients acceptables. La formulation pharmaceutique peut être sous la forme de capsules et est conditionnée dans un emballage-coque AI/AI étanche aux gaz de manière à maintenir sa stabilité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)