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1. (WO2017173551) METHOD FOR GENERATING PROGENITOR T CELLS FROM STEM AND/OR PROGENITOR CELLS AND USE OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/173551    International Application No.:    PCT/CA2017/050428
Publication Date: 12.10.2017 International Filing Date: 07.04.2017
IPC:
C12N 5/0797 (2010.01), A61K 35/17 (2015.01), C12N 5/0783 (2010.01)
Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO [CA/CA]; 27 King's College Circle Toronto, Ontario M5S 1A1 (CA)
Inventors: ZANDSTRA, Peter W.; (CA).
SHUKLA, Shreya; (CA)
Agent: MCMAHON, Eileen M.; (CA).
ARNOLDO, Maryanne; (CA).
DE FREITAS, Tasha; (CA).
FAN, Edward Tat Kau; (CA).
HUNDAL, Steve K.S.; (CA).
KOMARNICKI, Vanessa; (CA).
NELLES, Michelle; (CA).
REGULY, Teresa Ann; (CA).
ROWAND, Melanie; (CA)
Priority Data:
62/320,005 08.04.2016 US
Title (EN) METHOD FOR GENERATING PROGENITOR T CELLS FROM STEM AND/OR PROGENITOR CELLS AND USE OF SAME
(FR) PROCÉDÉ DE PRODUCTION DE CELLULES T PROGÉNITRICES À PARTIR DE CELLULES SOUCHES ET/OU PROGÉNITRICES ET SON UTILISATION
Abstract: front page image
(EN)The present disclosure provides a method for generating progenitor T cells from stem and/or progenitor cells comprising exposing the stem and/or progenitor cells to Notch ligand Delta- like-4 (DL4) and vascular adhesion molecule 1 (VCAM-1) under conditions suitable to generate progenitor T cells. The method provided is suitable for in vitro and in vivo pro-T cell generation. In vitro, the pro-T cells are generated under serum-free conditions. Cells produced using the method are provided as well as methods of using same.
(FR)La présente invention décrit un procédé de production de cellules T progénitrices à partir de cellules souches et/ou progénitrices comprenant l’exposition des cellules souches et/ou progénitrices à une molécule d’adhésion vasculaire 1 (VCAM-1) et Notch ligand Delta-like-4 (DL4) sous des conditions appropriées pour générer des cellules T progénitrices. Le procédé décrit convient à la production in vitro et in vivo de pro-cellules T. Les pro-cellules T in vitro sont produites sous des conditions sans sérum. Les cellules produites en utilisant le procédé sont décrites ainsi que des procédés pour leur utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)