Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017173367) EXTRACELLULAR VESICLES, METHODS OF MAKING THEM, AND METHODS OF REDUCING LIVER UPTAKE OF EXTRACELLULAR VESICLES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/173367 International Application No.: PCT/US2017/025550
Publication Date: 05.10.2017 International Filing Date: 31.03.2017
IPC:
C07K 14/54 (2006.01) ,A61K 9/127 (2006.01) ,C07K 14/715 (2006.01) ,C07K 14/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
715
for cytokines; for lymphokines; for interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer 6011 Executive Blvd., Suite 325 Rockville, MD 20852, US
IHSAN DOGRAMACI BILKENT UNIVERSITY [TR/TR]; BILKENT UNIVERSITY 06800 Ankara, TR
Inventors:
PAVLAKIS, George, N.; US
WATSON, Dionysios, Christos; US
FELBER, Barbara, K.; US
BAYIK, Defne; US
GURSEL, Ihsan; TR
BERGAMASCHI, Cristina; US
Agent:
LOCKYER, Jean, M.; US
BASTIAN, Kevin, L.; US
GAO, Chuan; US
GRAHAM, Jamie, L.; US
Priority Data:
62/316,27631.03.2016US
Title (EN) EXTRACELLULAR VESICLES, METHODS OF MAKING THEM, AND METHODS OF REDUCING LIVER UPTAKE OF EXTRACELLULAR VESICLES
(FR) VÉSICULES EXTRACELLULAIRES, LEURS PROCÉDÉS DE PRÉPARATION, ET MÉTHODES DE RÉDUCTION DE L'ABSORPTION HÉPATIQUE DES VÉSICULES EXTRACELLULAIRES
Abstract:
(EN) An isolated or purified extracellular vesicle comprising a membrane comprising a phospholipid bilayer and a heterodimeric complex of interleukin-15 and interleukin-15 receptor alpha is disclosed. Also provided are methods of preparing isolated or purified extracellular vesicles comprising a therapeutic protein, methods of reducing liver uptake of extracellular vesicles administered to a mammal, and methods of treating or preventing cancer in a mammal.
(FR) L'invention concerne une vésicule extracellulaire isolée ou purifiée comprenant une membrane comprenant une bicouche phospholipidique et un complexe hétérodimère de l'interleukine-15 et du récepteur alpha de l'interleukine-15. L'invention concerne également des procédés de préparation de vésicules extracellulaires isolées ou purifiées comprenant une protéine thérapeutique, des méthodes de réduction de l'absorption hépatique des vésicules extracellulaires administrées à un mammifère, et des méthodes de traitement ou de prévention du cancer chez un mammifère.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)