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1. (WO2017173349) BCMA BINDING MOLECULES AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/173349    International Application No.:    PCT/US2017/025516
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Sat Apr 01 01:59:59 CEST 2017
IPC: A61K 35/12
A61K 38/17
A61K 39/395
C07K 14/705
C07K 16/30
Applicants: KITE PHARMA, INC.
Inventors: WILTZIUS, Jed
ALVAREZ RODRIGUEZ, Ruben
Title: BCMA BINDING MOLECULES AND METHODS OF USE THEREOF
Abstract:
The invention provides antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs), and engineered T cell receptors, polynucleotides encoding the same, and in vitro cells comprising the same. The polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered CAR T cell therapy for the treatment of a patient suffering from a cancer. In one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.