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1. (WO2017173229) METHODS AND COMPOSITIONS FOR PREVENTING INFECTION BY A VIBRIO SPECIES
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Pub. No.: WO/2017/173229 International Application No.: PCT/US2017/025305
Publication Date: 05.10.2017 International Filing Date: 31.03.2017
IPC:
C12R 1/91 (2006.01) ,A01N 63/02 (2006.01) ,C12N 7/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
R
INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1
Micro-organisms
91
Cell lines
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63
Biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, animals, e.g. nematodes, or substances produced by, or obtained from micro-organisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
02
Substances produced by, or obtained from, micro-organisms or animals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants: TUFTS UNIVERSITY[US/US]; 136 Harrison Avenue Boston, Massachusetts 02111, US
Inventors: CAMILLI, Andrew; US
CAIRNS, Lynne; US
YEN, Minmin; US
Agent: GUTERMAN, Sonia K.; US
Priority Data:
62/316,70401.04.2016US
Title (EN) METHODS AND COMPOSITIONS FOR PREVENTING INFECTION BY A VIBRIO SPECIES
(FR) PROCÉDÉS ET COMPOSITIONS POUR PRÉVENIR UNE INFECTION PAR UNE ESPÈCE VIBRIO
Abstract:
(EN) Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the compositions containing two or more strains of lytic bacteriophage that infect and kill Vibrio cells. The bacteriophage are virulent, which replicate intracellularly and lyse and kill the bacteria. Use of two or more strains in a single treatment, as a result of a rate of mutation of the bacteria to simultaneous resistance to all of the bacteriophage to be so low as to be negligible, reduces appearance of phage-resistant bacteria to statistical negligibility. Normal human microbial flora species were not affected. In alternative embodiments of the method and the composition, antibiotic agents or other treatment agents can be administered with a cocktail of the plurality of bacteriophage strains.
(FR) La présente invention concerne des compositions et des procédés pour prévenir, améliorer ou traiter une maladie causée par une espèce du genre bactérien Vibrio, par exemple, le choléra causé par V. cholerae, les compositions contenant deux ou plus de deux souches de bactériophage lytique qui infectent et tuent les cellules de Vibrio. Les bactériophages sont virulents, se répliquent de façon intracellulaire et lysent et tuent les bactéries. L'utilisation de deux ou plus de deux souches dans un traitement unique, en raison du fait que le taux de mutation des bactéries pour une résistance simultanée à l’ensemble des bactériophages est tellement faible qu’il est négligeable, réduit l’apparition de bactéries résistantes aux phages à un niveau statistiquement négligeable. Les espèces de la flore microbienne humaine normale ne sont pas affectées. Dans d'autres modes de réalisation du procédé et de la composition, des agents antibiotiques ou d'autres agents de traitement peuvent être administrés avec un cocktail de la pluralité de souches de bactériophage.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)