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1. (WO2017173103) REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/173103    International Application No.:    PCT/US2017/025063
Publication Date: 05.10.2017 International Filing Date: 30.03.2017
Chapter 2 Demand Filed:    29.08.2017    
IPC:
A61K 31/365 (2006.01), A61K 31/055 (2006.01), A61K 31/55 (2006.01), C12N 5/16 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027 (US)
Inventors: JACOBS, Christopher; (US).
SPASIC, Milos; (US)
Agent: RAGUSA, Paul, A.; (US).
RAGUSA, Paul, A.; (US)
Priority Data:
62/315,545 30.03.2016 US
Title (EN) REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH
(FR) RÉGULATION DE L'EXPRESSION GÉNIQUE PAR MODULATION DE LA LONGUEUR DES CILS PRIMAIRES
Abstract: front page image
(EN)The presently disclosed subject matter relates to methods of regulating gene expression in a cell by modulating the length of a primary cilia of a cell, wherein such modulation can modulate the mechanosensitivity of the cell. The presently disclosed subject matter also provides for methods of treating ciliopathies and osteoporosis in a subject by increasing the length of a primary cilia of a cell in a subject.
(FR)La présente invention concerne des procédés de régulation de l'expression génique dans une cellule par modulation de la longueur des cils primaires d'une cellule, ladite modulation pouvant moduler la mécanosensibilité de la cellule. La présente invention concerne également des procédés de traitement de ciliopathies et de l'ostéoporose chez un sujet par l'augmentation de la longueur des cils primaires d'une cellule chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)