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1. (WO2017173092) METHODS FOR GENOME EDITING IN ZYGOTES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/173092    International Application No.:    PCT/US2017/025039
Publication Date: 05.10.2017 International Filing Date: 30.03.2017
IPC:
C12N 9/22 (2006.01), C12N 15/11 (2006.01), C12N 15/113 (2010.01), C12N 15/10 (2006.01), C12Q 1/68 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607 (US)
Inventors: CHEN, Sean; (US).
MODZELEWSKI, Andrew J.; (US).
HE, Lin; (US).
LEE, Angus; (US)
Agent: BORDEN, Paula A.; (US)
Priority Data:
62/316,289 31.03.2016 US
Title (EN) METHODS FOR GENOME EDITING IN ZYGOTES
(FR) PROCÉDÉS D'ÉDITION DE GÉNOME DANS LES ZYGOTES
Abstract: front page image
(EN)The present disclosure provides methods of modifying the genome of a mammalian zygote. The present disclosure provides methods of modulating transcription in a mammalian zygote. The present disclosure provides methods of labeling a target nucleic acid in the genome of a mammalian zygote. The present disclosure provides methods of delivering a ribonucleoprotein complex into a mammalian zygote. The present disclosure provides methods of delivering a polypeptide or a nucleic acid into a mammalian zygote.
(FR)La présente invention concerne des procédés de modification du génome d'un zygote de mammifère. La présente invention concerne des procédés de modulation de la transcription dans un zygote mammifère. La présente invention concerne des procédés de marquage d'un acide nucléique cible dans le génome d'un zygote mammifère. La présente invention concerne des procédés d'administration d'un complexe de ribonucléoprotéine dans un zygote de mammifère. La présente invention concerne des procédés d'administration d'un polypeptide ou d'un acide nucléique dans un zygote mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)