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1. (WO2017173064) OLIGODENDROCYTE PROGENITOR CELL COMPOSITIONS

Pub. No.:    WO/2017/173064    International Application No.:    PCT/US2017/024986
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Fri Mar 31 01:59:59 CEST 2017
IPC: C12N 5/00
C12N 5/074
C12N 5/079
Applicants: ASTERIAS BIOTHERAPEUTICS, INC.
Inventors: WHITELEY, Erik Michael
SHOUKAT-MUMTAZ, Uzma
SRIVASTAVA, Rashi
MANLEY, Nathan Charles
CASE, Casey Christopher
Title: OLIGODENDROCYTE PROGENITOR CELL COMPOSITIONS
Abstract:
Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.