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1. (WO2017173027) APTAMERS REDUCE SICKLE HEMOGLOBIN POLYMERIZATION

Pub. No.:    WO/2017/173027    International Application No.:    PCT/US2017/024918
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Fri Mar 31 01:59:59 CEST 2017
IPC: C12N 15/115
A61K 31/7088
A61P 7/06
Applicants: THE JOHNS HOPKINS UNIVERSITY
Inventors: CASELLA, James F.
BARRON-CASELLA, Emily
KEEFER, Jeffrey R.
FORTENBERRY, Yolanda
PURVIS, Shirley H.
Title: APTAMERS REDUCE SICKLE HEMOGLOBIN POLYMERIZATION
Abstract:
The presently disclosed subject matter provides methods for reducing sickling of an erythrocyte comprising sickle hemoglobin (HbS) by introducing polynucleotide aptamers into the erythrocyte. The polynucleotide aptamers specifically bind to HbS to inhibit polymerization of the HbS without affecting the oxygen affinity of the HbS.