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1. (WO2017172914) METHODS AND COMPOSITIONS FOR MODULATING FRATAXIN EXPRESSION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/172914    International Application No.:    PCT/US2017/024745
Publication Date: 05.10.2017 International Filing Date: 29.03.2017
IPC:
A61K 31/4178 (2006.01), A61P 25/28 (2006.01), A61K 31/551 (2006.01), A61K 31/5517 (2006.01), C07D 487/04 (2006.01)
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street Madison, Wisconsin 53726 (US)
Inventors: ANSARI, Aseem; (US).
ERWIN, Graham; (US).
GRIESHOP, Matthew; (US)
Agent: HELMICH, Kate, E.; (US)
Priority Data:
62/315,466 30.03.2016 US
62/366,700 26.07.2016 US
Title (EN) METHODS AND COMPOSITIONS FOR MODULATING FRATAXIN EXPRESSION
(FR) PROCÉDÉS ET COMPOSITIONS DE MODULATIONS DE L'EXPRESSION DE LA FRATAXINE
Abstract: front page image
(EN)The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
(FR)La présente technologie porte sur des compositions et des procédés de modulation de l'expression de gènes, qui incluent une séquence d'oligonucléotides cibles, comme des répétitions d'une séquence particulière d'oligonucléotides contenant 3 à 10 nucléotides. Selon des aspects particuliers, la présente technologie porte sur des agents dont la formule est A-L-B, -L- étant un liant; A- étant un groupe fonctionnel de liaison Brd4; et -B étant un groupe fonctionnel de liaison d'acide nucléique, comme un polyamide ou un oligonucléotide complémentaire, qui se lie spécifiquement à la séquence d'oligonucléotides cibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)