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1. (WO2017172894) METHODS OF PREVENTING, TREATING AND DETECTING COLORECTAL CANCER USING BUTYRATE PRODUCING BACTERIA
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Pub. No.: WO/2017/172894 International Application No.: PCT/US2017/024718
Publication Date: 05.10.2017 International Filing Date: 29.03.2017
IPC:
C12Q 1/68 (2006.01) ,C12Q 1/04 (2006.01) ,C12Q 1/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK[US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027, US
Inventors: LIPKIN, W., Ian; US
WILLIAMS, Brent, L.; US
COUTO-RODRIGUEZ, Mara; US
Agent: CARNEY, Bonnie, K.; US
LEASON, David; US
Priority Data:
62/315,37130.03.2016US
Title (EN) METHODS OF PREVENTING, TREATING AND DETECTING COLORECTAL CANCER USING BUTYRATE PRODUCING BACTERIA
(FR) PROCÉDÉS DE PRÉVENTION, DE TRAITEMENT ET DE DÉTECTION DU CANCER COLORECTAL À L'AIDE DE BACTÉRIES PRODUISANT DU BUTYRATE
Abstract:
(EN) The invention provides for methods for treating and preventing colorectal cancer, non-dysplastic serrated polyps, or serrated crypt foci in a subject by administering butyrate producing bacteria, dietary fiber, sodium butyrate, or a combination thereof. The invention also provides methods for detecting, determining and/or diagnosing colorectal cancer, non-dysplastic serrated polyps, or serrated crypt foci in a subject by detection of the level of butyrate producing bacteria in a sample, as well as the alpha diversity, the operational taxonomic units, the level of bacteria Lactobacillales, and the level of CoA and BcoA nucleic acid.
(FR) L'invention concerne des procédés de traitement et de prévention du cancer colorectal, des polypes dentelés non dysplasiques, ou des foyers de cryptes dentelés chez un sujet par l'administration de bactéries produisant du butyrate, de fibres alimentaires, de butyrate de sodium, ou d'une combinaison de ceux-ci. L'invention concerne également des procédés pour détecter, déterminer et/ou diagnostiquer un cancer colorectal, des polypes dentelés non dysplasiques, ou des foyers de cryptes dentelés chez un sujet en détectant le taux de bactéries produisant du butyrate dans un échantillon, ainsi que la diversité alpha, les unités taxonomiques opérationnelles, le taux de bactéries Lactobacillales, et le taux d'acide nucléique CoA et BcoA.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)