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1. (WO2017172733) ANTI-RYK ANTIBODIES AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/172733 International Application No.: PCT/US2017/024494
Publication Date: 05.10.2017 International Filing Date: 28.03.2017
IPC:
C07K 16/00 (2006.01) ,C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street, 5th Floor Oakland, California 94607, US
Inventors: ZOU, Yimin; US
Agent: NOVOM, Antony; US
WAGENKNECHT, Raymond; US
Priority Data:
62/314,02528.03.2016US
Title (EN) ANTI-RYK ANTIBODIES AND METHODS OF USING THE SAME
(FR) ANTICORPS ANTI-RYK ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Methods for inhibiting degeneration of a neuron, methods of treating a neurological/neurodegenerative disease, methods of modulating the directional growth of a neuron, and methods of interfering with the interaction of Wnt and Ryk are provided herein. Also provided are isolated anti-Ryk antibodies and antibody fragments that specifically bind to a binding domain of Wnt.
(FR) L'invention concerne des procédés permettant d'inhiber la dégénérescence d'un neurone, des méthodes de traitement d'une maladie neurologique/neurodégénérative, des procédés de modulation de la croissance directionnelle d'un neurone, et des procédés d'interférence avec l'interaction de Wnt et Ryk. Des anticorps anti-Ryk isolés et des fragments d'anticorps qui se lient spécifiquement à un domaine de liaison de Wnt sont en outre décrits.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)