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1. (WO2017172622) PAN FILOVIRUS VACCINE COMPOSITIONS AND METHODS OF MAKING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/172622    International Application No.:    PCT/US2017/024320
Publication Date: 05.10.2017 International Filing Date: 27.03.2017
IPC:
A61K 39/12 (2006.01), C07K 14/08 (2006.01), C07K 16/10 (2006.01), C12N 7/00 (2006.01), C12N 15/40 (2006.01), C12N 15/86 (2006.01)
Applicants: INTEGRATED BIOTHERAPEUTICS, INC. [US/US]; 4 Research Court Suite 100 Rockville, Maryland 20850 (US).
INTEGRAL MOLECULAR, INC. [US/US]; 3711 Market Street Suite 100 Philadelphia, Pennsylvania 19104 (US)
Inventors: AMAN, Mohammad Javad; (US).
HOWELL, Katie A.; (US).
DAVIDSON, Edgar; (US).
DORANZ, Benjamin J.; (US)
Agent: HOLTZ, William A.; (US).
HAANES, Betsy; (US).
BLUM, Anthony F.; (US).
BRAUNEL, Matthew A.; (US).
COLVIN, Katherine E.; (US).
DAVIS, J. Wendy; (US).
GERLACH, Robert D.; (US).
HIMICH, Matthew J.; (US).
JINKINS, David B.; (US).
KERCHER, Kevin M.; (US).
MOUSSAVI, Sartouk H.; (US).
MUSCH, Jonathan G.; (US).
NEPPLE, Michael L.; (US).
NORMAN, Alan H.; (US).
PARKS, Michael A.; (US).
POLCYN, Thomas A.; (US).
RITCHEY, Steven M.; (US).
ROMANO, Charles P.; (US).
SCHWENT, Jason M.; (US).
SMITH, Clyde L.; (US).
VOLK, Benjamin L.; (US)
Priority Data:
62/314,009 28.03.2016 US
62/423,584 17.11.2016 US
Title (EN) PAN FILOVIRUS VACCINE COMPOSITIONS AND METHODS OF MAKING
(FR) COMPOSITIONS DE VACCIN CONTRE LE PAN-FILOVIRUS ET LEURS PROCÉDÉS DE FABRICATION
Abstract: front page image
(EN)[0001] Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
(FR)L'invention concerne des procédés d'incorporation de substitutions de résidus spécifiés dans une GP de filovirus afin d'augmenter l'immunogénicité et/ou d'élargir la réactivité croisée de la réponse immunitaire protectrice contre d'autres membres de filovirus. L'invention concerne également des GP de filovirus mutantes comprenant de telles substitutions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)