Search International and National Patent Collections

1. (WO2017172615) POLYMORPHIC FORMS OF AN OXYSTEROL AND METHODS OF MAKING THEM

Pub. No.:    WO/2017/172615    International Application No.:    PCT/US2017/024302
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Tue Mar 28 01:59:59 CEST 2017
IPC: A61K 35/32
A61K 45/06
A61L 27/00
A61P 19/10
C07J 9/00
Applicants: WARSAW ORTHOPEDIC, INC.
Inventors: HARRINGTON, Roger, E.
JACOBS, Jerbrena, C.
Title: POLYMORPHIC FORMS OF AN OXYSTEROL AND METHODS OF MAKING THEM
Abstract:
Compositions and methods for preparing an OXY133 polymorph are provided. This compositions and methods include subjecting a slurry of OXY133 to conditions sufficient to convert OXY133 to the OXY133 polymorph Form A, polymorph Form B, polymorph Form C, polymorph Form D, polymorph Form E, polymorph Form F, polymorph Form G, polymorph Form H, polymorph Form I or a mixture thereof. A polymorph of OXY133 is also provided and that polymorph can be polymorph Form A, polymorph Form B, polymorph Form C, polymorph Form D, polymorph Form E, polymorph Form F, polymorph Form G, polymorph Form H, polymorph Form I or a mixture thereof. Pharmaceutical compositions including OXY133 polymorphs are also provided.