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1. (WO2017172368) INDOLINE ANALOGS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/172368    International Application No.:    PCT/US2017/022682
Publication Date: 05.10.2017 International Filing Date: 16.03.2017
IPC:
C07D 209/04 (2006.01), C07D 209/34 (2006.01), A61K 31/404 (2006.01)
Applicants: ONCTERNAL THERAPEUTICS, INC. [US/US]; 3525 Del Mar Heights Road, #821 San Diego, CA 92130-2122 (US)
Inventors: WEBBER, Stephen, E.; (US)
Agent: MALLON, Joseph, J.; (US)
Priority Data:
62/417,621 04.11.2016 US
62/316,156 31.03.2016 US
Title (EN) INDOLINE ANALOGS AND USES THEREOF
(FR) ANALOGUES D'INDOLINE ET LEURS UTILISATIONS
Abstract: front page image
(EN)Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the indoline derivatives, methods of synthesizing the same, methods of treating using same, and assays for identifying the inhibitors of EWS-FLI1 oncoprotein.
(FR)L'invention concerne des composés dérivés d'indoline agissant en tant qu'inhibiteurs du facteur de transcription EWS-FLI1. L'invention concerne également des compositions pharmaceutiques à base desdits dérivés d'indoline, des procédés de synthèse de ceux-ci, des méthodes de traitement au moyen de ceux-ci, et des dosages permettant d'identifier les inhibiteurs de l'oncoprotéine EWS-FLI1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)