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1. (WO2017171631) NON-ACTIVATED T CELLS EXPRESSING EXOGENOUS VIRUS-SPECIFIC T CELL RECEPTOR (TCR)

Pub. No.:    WO/2017/171631    International Application No.:    PCT/SG2016/050164
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Fri Apr 01 01:59:59 CEST 2016
IPC: C12N 5/0783
A61K 35/17
Applicants: LION TCR PTE. LTD.
Inventors: BERTOLETTI, Antonio
KOH, Sarene
Title: NON-ACTIVATED T CELLS EXPRESSING EXOGENOUS VIRUS-SPECIFIC T CELL RECEPTOR (TCR)
Abstract:
The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof.