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1. (WO2017171249) COMPOSITION FOR PROMOTING DIFFERENTIATION OF SKIN CELLS AND METHOD FOR SCREENING FOR MATERIALS PROMOTING DIFFERENTIATION OF SKIN CELLS
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Pub. No.: WO/2017/171249 International Application No.: PCT/KR2017/002211
Publication Date: 05.10.2017 International Filing Date: 28.02.2017
IPC:
A61K 48/00 (2006.01) ,A61K 31/713 (2006.01) ,A61K 8/60 (2006.01) ,A23L 33/13 (2016.01) ,G01N 33/50 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
60
Sugars; Derivatives thereof
[IPC code unknown for A23L 33/13]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
(주)아모레퍼시픽 AMOREPACIFIC CORPORATION [KR/KR]; 서울시 용산구 한강대로 106 106, Hangang-daero, Yongsan-gu, Seoul 04386, KR
Inventors:
손의동 SON, Eui Dong; KR
김형준 KIM, Hyoung June; KR
김규한 KIM, Kyu Han; KR
박선영 PARK, Sun Young; KR
이성훈 LEE, Sung Hoon; KR
최민식 CHOI, Min Sik; KR
조은경 CHO, Eun-Gyung; KR
이태룡 LEE, Tae Ryong; KR
Agent:
김순영 KIM, Sun-young; KR
Priority Data:
10-2016-003683428.03.2016KR
Title (EN) COMPOSITION FOR PROMOTING DIFFERENTIATION OF SKIN CELLS AND METHOD FOR SCREENING FOR MATERIALS PROMOTING DIFFERENTIATION OF SKIN CELLS
(FR) COMPOSITION POUR STIMULER LA DIFFÉRENCIATION DE CELLULES CUTANÉES ET PROCÉDÉ DE CRIBLAGE DE MATÉRIAUX STIMULANT LA DIFFÉRENCIATION DE CELLULES CUTANÉES
(KO) 피부 세포 분화 촉진용 조성물 및 피부 세포 분화 촉진 물질의 스크리닝 방법
Abstract:
(EN) Disclosed in the present specification are a composition for promoting the differentiation of skin cells and a method for screening for materials promoting the differentiation of skin cells. The composition for promoting the differentiation of skin cells, of the present invention, inhibits the expression or activity of JAB-1, thereby inhibiting the migration of psoriasin into the cell nucleus so as to enable the differentiation of skin cells to be effectively promoted. Therefore, the composition is effective in skin moisturization, skin barrier function strengthening, or treatment for atopy alleviation. In addition, according to one aspect, the method for screening for materials promoting the differentiation of skin cells treats keratinocytes with test materials and identifies the relative expression levels of JAB-1, thereby enabling materials for promoting the differentiation of corneocytes to be conveniently, rapidly and efficiently screened for.
(FR) La présente invention concerne une composition pour stimuler la différenciation de cellules cutanées et un procédé de criblage de matériaux stimulant la différenciation de cellules cutanées. La composition pour stimuler la différenciation de cellules cutanées, selon la présente invention, inhibe l'expression ou l'activité de JAB-1, de façon à inhiber la migration de psoriasine dans le noyau cellulaire de façon à permettre que la différenciation de cellules cutanées soit efficacement stimulée. Par conséquent, la composition est efficace dans l'hydratation de la peau, le renforcement de la fonction de barrière cutanée, ou le traitement pour l'atténuation de l'atopie. De plus, selon un aspect, le procédé de criblage de matériaux stimulant la différenciation de cellules cutanées traite des kératinocytes avec des matériaux d’essai et identifie les taux d'expression relatifs de JAB-1, de façon à permettre que des matériaux stimulant la différenciation de cornéocytes soient criblés de façon pratique, rapide et efficace.
(KO) 본 명세서에는, 피부 세포 분화 촉진용 조성물과 피부 세포 분화 촉진 물질의 스크리닝 방법이 개시된다. 본 발명의 피부 세포 분화 촉진용 조성물은 JAB-1의 발현 또는 활성을 억제하고, 그 결과 서라이어신의 세포 핵내로의 이동을 억제하여, 피부 세포 분화를 효과적으로 촉진할 수 있다. 따라서, 상기 조성물은 피부 보습, 피부 장벽 기능 강화 또는 아토피 완화 치료에 효과적이다, 또한, 일 측면에 따른 피부 세포 분화 촉진 물질 스크리닝 방법은, 각질 형성 세포에 시험물질을 처리하고 JAB-1의 상대적 발현 정도를 확인함으로써, 간편하고 신속하며 효율적으로 각질세포 분화 촉진 물질을 스크리닝할 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)